2016

Trinkle-Mulcahy L and Sleeman, JE..The Cajal Body and the Nucleolus: "In a Relationship" or "It's Complicated"?.RNA Biol. 2016 (Epub ahead of print).

Audas TE, Audas DE, Jacob MD, Ho JJ, Khacho M, Wang M, Perera JK, Gardiner C, Bennett CA, Head T, Kryvenko ON, Jorda M, Daunert S, Malhotra A, Trinkle-Mulcahy L, Gonzalgo ML, Lee S. Adaptation to Stressors by Systemic Protein Amyloidogenesis. Dev Cell 39:155-168, 2016.

Mehta V and Trinkle-Mulcahy L. Recent advances in large-scale protein interactome mapping. F1000Res 5:782, 2016.

2015

Ard R, Mulatz K, Pomoransky JL, Parks RJ, Trinkle-Mulcahy L, Bell JC, Gee SH. Regulation of Macropinocytosis by Diacylglycerol Kinase ζ. PLoS One. 10:e0144942, 2015.

Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, Knott GJ, Iyer KS, Ho D, Newcombe EA, Hosoki K, Goshima N, Kawaguchi T, Hatters D, Trinkle-Mulcahy L, Hirose T, Bond CS, Fox AH.Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J Cell Biol. 210:529-39, 2015.

Platani M, Trinkle-Mulcahy L, Porter M, Jeyaprakash AA, Earnshaw WC. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.J Cell Biol.21:45-62, 2015.

Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP. Phosphorylation of SAF-A/hnRNP-U serine 59 by polo-like kinase 1 (PLK1) is required for mitosis. Mol Cell Biol.35:2699-713, 2015.

Lam, YW, Trinkle-Mulcahy, L. New insights into nucleolar structure and function. F1000Prime Rep 2015, 7:48.

Baldwin RM, Bejide, M, Trinkle-Mulcahy L, Côté, J.Identification of the prmt1v1 and prmt1v2 specific interactomes by quantitative mass spectrometry in breast cancer cells. Proteomics 15:2187-97, 2015.

Fox, A, Mehta, V, Boulon, S, Trinkle-Mulcahy, L. Extracting, enriching, and identifying nuclear body sub-complexes using label-based quantitative mass spectrometry. Methods Mol Biol.1262:215-38, 2015.

2014

De Wever V, Nasa I, Chamousset D, Lloyd D, Nimick M, Xu H, Trinkle-Mulcahy L, Moorhead GB.The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif. Biochem Biophys Res Commun. 453:432-7, 2014.

Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. EMBO J. 33:2676-91, 2014.

Lariviére, N, Law, J and Trinkle-Mulcahy, L. Dissection of a Novel Autocrine Signaling Pathway via Quantitative Secretome and Interactome Mapping. J. Proteome Res. 13:3432-43, 2014.

Douglas, P, Ye, R, Trinkle-Mulcahy, L, Neal, JA, De Wever, V, Morrice, NA, Meek, K, Lees-Miller, SP .Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Biosci Rep 34:e00113, 2014

Sleeman, JE and Trinkle-Mulcahy, L. Nuclear bodies: new insights into assembly/dynamics and disease relevance. Curr Op Cell Biol.28:76-83, 2014.

Prescott, AR, Bales, A, James, J, Trinkle-Mulcahy, L, Sleeman, JE. Time-resolved quantitative proteomics implicates the core snRNP protein, SmB, together with the Survival of Motor Neuron protein, in neural trafficking. J Cell Science 127:812-27, 2014.

2013

Jacob MD, Audas TE, Uniacke J, Trinkle-Mulcahy L, Lee S.Environmental Cues Induce a Long Noncoding RNA-dependent Remodeling of the Nucleolus. Mol Biol Cell. 24:2943-53, 2013.

Mehta, V., Trinkle-Mulcahy, L. Novel methods for studying multiprotein complexes in vivo. F1000 Prime Rep. 5:30, 2013.

Prévost, M., Chamousset, D., Nasa, I., Freele, E., Morrice, N., Moorhead, G., Trinkle-Mulcahy, L.Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan. Mol Cell Proteomics 12:1468-86, 2013.

2012

Skene-Arnold TD, Luu HA, Uhrig G, De Wever V, Nimick M, Maynes J, Fong A, James MN, Trinkle-Mulcahy L, Moorhead GB, Holmes CF. Molecular mechanisms underlying the interaction of Protein Phosphatase-1c with apoptotic ASPP proteins. Biochem J. 449:649-59, 2012.

De Wever V, Lloyd DC, Nasa I, Nimick M, Trinkle-Mulcahy L, Gourlay R, Morrice N, Moorhead GB. Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21 PLoS One. 7(6):e39510, 2012.

Trinkle-Mulcahy L .Resolving protein interactions and complexes by affinity purification followed by label-based quantitative mass spectrometry.Proteomics.12:1623-38, 2012.

Swift, S. and Trinkle-Mulcahy, L. To bin or not to bin: Balancing the trade-off between signal intensity, spatial and time resolution in biological imaging In Focus 26:5-14.

2011

Ferrar, T., Chamousset, D., De Wever, V., Nimick, M., Andersen, J., Trinkle-Mulcahy, L. and Moorhead, GL. Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein. Biology Open1:128-139, 2011.

2010

Chamousset, D., De Wever, V., Moorhead, G., Chen, Y., Boisvert, F.M., Lamond, A.I. and Trinkle-Mulcahy, L. RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits. Mol. Biol. Cell 21:4212-26, 2010.

Schmitz MH, Held M, Janssens V, Hutchins JR, Hudecz O, Ivanova E, Goris J, Trinkle-Mulcahy L, Lamond AI, Poser I, Hyman AA, Mechtler K, Peters JM, Gerlich DW .Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol 12:886-93, 2010.

Chamousset D, Mamane S, Boisvert FM, Trinkle-Mulcahy L .Efficient extraction of nucleolar proteins for interactome analyses .Proteomics 10:3045-50, 2010.

Boulon S, Ahmad Y, Trinkle-Mulcahy L, Verheggen C, Cobley A, Gregor P, Bertrand E, Whitehorn M, Lamond A. Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners. Mol Cell Proteomics 9:861-79, 2010.

Ottawa

On the Up: Ontario has always been known for its groundbreaking science - now get ready for its biotech.The Scientist 24:9-13, 2010.

 

2009

Trinkle-Mulcahy L. Aberrant mRNA transcripts and nonsense-mediated decay F1000 Biology Reports. 1:93, 2009.

2008

Trinkle-Mulcahy L., Boulon S., Lam Y.W., Urcia R., Boisvert F.M., Vandermoere F., Morrice N.A., Swift S., Rothbauer U., Leonhardt H. and Lamond A.I. Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes. J Cell Biol. 183:223-39, 2008.

Moorhead GB, Trinkle-Mulcahy L, Nimick M, De Wever V, Campbell DG, Gourlay R, Lam YW, Lamond AI. Moorhead GB, Trinkle-Mulcahy L, Nimick M, De Wever V, Campbell DG, Gourlay R, Lam YW, Lamond AI .Displacement affinity chromatography of protein phosphatase 1 (PP1) complexes. BMC Biochem. 9:28, 2008.

Trinkle-Mulcahy, L. and Lamond, A.I. Nuclear functions in space and time: Gene expression in a dynamic, constrained environment. FEBS Lett. 582:1960-70, 2008.

2007

Trinkle-Mulcahy, L. and Lamond, A.I. Toward a high-resolution view of nuclear dynamics. Science. 318:1402-07, 2007.

Trinkle-Mulcahy, L. and Swift, S. Caught on camera with another protein - Just good friends or something more? A Guide to Localization, Colocalization and Interaction on the Light Microscope. In Focus (Proceedings of the Royal Microscopy Society), 8:4-15, 2007.

Moorhead, G.B.G., Trinkle-Mulcahy, L. and Ulke-Lemee, A. Emerging roles of nuclear protein phosphatases. Nat. Rev. Mol. Cell Biol. 3:234-44, 2007.

Ulke-Lemée A, Trinkle-Mulcahy L, Chaulk S, Bernstein NK, Morrice N, Glover M, Lamond AI and Moorhead GB. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Biochim Biophys Acta. 10:1339-50, 2007.

2006

Trinkle-Mulcahy, L., Andersen, J., Lam, Y.W., Moorhead, G., Mann, M. and Lamond, A.I. Repo-Man recruits PP1γ to chromatin and is essential for cell viability. J. Cell Biol. 172:679-92, 2006.

Vagnarelli, P., Hudson, D.F., Ribeiro, S.A., Trinkle-Mulcahy, L., Spence, J.M., Lai, F., Farr, C.J., Lamond, A.I. and Earnshaw, W.C.. Condensin and Repo-Man/PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat. Cell Biol. 8:1133-42, 2006.

Trinkle-Mulcahy, L.
and Lamond, A.I. Mitotic phosphatases: no longer silent partners. Current Opinion in Cell Biology. 18:623-31, 2006.

Leung, A.K., Trinkle-Mulcahy, L., Lam, Y.W., Andersen, J.S., Mann, M. and Lamond, A.I. NoPdb: Nucleolar Proteome Database. Nucleic Acids Res. 34:D218-20, 2006.

Trinkle-Mulcahy, L., Chusainow, J., Lam, Y.W., Swift, S. and Lamond, A.I. Visualization of intracellular PP1 targeting through transiently and stably expressed fluorescent protein fusions. Methods in Molecular Biology. Vol.. 365:133-54; Protein Phosphatase Protocols, Ed. G. Moorhead, Humana Press, 2006.


2005

Lam, Y.W., Trinkle-Mulcahy, L. and Lamond, A.I. The Nucleolus. J. Cell Sci., 118:1335-1337, 2005.


Swift, S.R., Thomson, C., Appleton, P., Lam, Y.W. and L. Trinkle-Mulcahy. Basic principles deconvolution microscopy. Proc. Royal Mic. Soc., 40, 2005.

Chusainow, J.C., Ajuh, P.M., Trinkle-Mulcahy, L., Sleeman, J.E., Ellenberg, J. and Angus I. Lamond. "FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35" RNA, 11:1201-14, 2005

2004

Swift, S.R. and L. Trinkle-Mulcahy. Basic principles of FRAP, FLIM and FRET. Proc. Royal Mic. Soc., 39:3-10, 2004.

2003

Trinkle-Mulcahy, L., Andrews, P.D., Wickramasinghe, S., Sleeman, J., Prescott, A., Lam, Y.W., Lyon, C., Swedlow, J.R. and Lamond, A.I. Time-lapse imaging reveals dynamic relocalization of PP1γ throughout the mammalian cell cycle. Mol. Biol. Cell, 14:107-117, 2003.

Sleeman, J.E., Trinkle-Mulcahy, L., Prescott, A., Ogg, S.C. and Angus I. Lamond. "Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo" J. Cell Sci., 116:2039-2050, 2003.

2002

Kimber, W.A., Trinkle-Mulcahy, L., Cheung, P.C.F., Deak, M., Marsden, L.J., Kieloch, A., Watt, S., Javiers, R.T., Gray, A., Downes, C.P., Lucocq, J.M. and Alessi, D.R. "Evidence that the tandem-pleckstrin-homology-domain-containing-protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo." Biochem. J., 361:525-536, 2002.

2001

Trinkle-Mulcahy, L., Sleeman, J.E. and Lamond, A.I. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J. Cell Science. 114:4219-4228, 2001.

Miller, G., Panov, K.I., Friedrich, J.K., Trinkle-Mulcahy, L., Lamond, A.I. and Zomerdijk, J.C.B.M. hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. EMBO J. 20:1373-1382, 2001.

Cheung, P.C.F., Trinkle-Mulcahy, L., Cohen, P. and Lucocq, J. M. Characterisation of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Biochem. J. 355:113-121, 2001.

2000

1999

Trinkle-Mulcahy, L., Ajuh, P., Prescott, A., Cohen, S., Claverie-Martin, F., Lamond, A.I. and Cohen, P. Nuclear organisation of NIPP-1, a nuclear subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors. J. Cell Science. 112:157-168, 1999.

Chang, A.C.YU., Sohlberg, B., Trinkle-Mulcahy, L., Claverie-Martin, F., Cohen, P. and Cohen, S.N. Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. Gene. 240:45-55, 1999.

1998

1997

Kreivi, J.-P., Trinkle-Mulcahy, L., Lyon, C.E., Morrice, N.A., Cohen, P. and Lamond, A.I. Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. FEBS Lett. 420:57-62, 1997.

Siegman, M.J., Mooers, S.U., Li, C., Narayan, S., Trinkle-Mulcahy, L., Hartshorne, D.J., and Butler, T.M. Phosphorylation of a high molecular weight (~600 kDa) protein regulates catch in invertebrate smooth muscle. J. Mus. Res. Cell Motility. 18: 655-670, 1997.

Siegman, M.J., Butler, T.M. Mooers, S.U., Trinkle-Mulcahy, L., Narayan, S., Stirewalt, W., and Starcher, B. Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition and force output. Am. J. Physiol. 272: G1560-G1570, 1997.

Siegman, M.J., Butler, T.M., Mooers, S.U., Trinkle-Mulcahy, L., Narayan, S., Adam, L., Chacko, S., Haase, H., and Morano, I. Hypertrophy of colonic smooth muscle: contractile proteins, shortening velocity and regulation. Am. J. Physiol. 272:G1571-G1580, 1997.

1996

1995

Trinkle-Mulcahy, L., Ichikawa, K., Hartshorne, D.J., Siegman, M.J., and Butler T.M. Thiophosphorylation of the 130 kDa subunit is associated with a decreased activity of myosin light chain phosphatase in alpha-toxin-permeabilized smooth muscle. J. Biol. Chem. 270:18191-18194, 1995.

1994

Trinkle-Mulcahy, L., M.J. Siegman and T.M. Butler. Metabolic characteristics of alpha-toxin permeabilized smooth muscle. Am. J. Physiol. 266:C1673-C1683, 1994.

1993

1992

Trinkle, L.A., D. Beasley and R.S. Moreland. Interleukin-1beta alters actin expression and inhibits contraction of rat thoracic aorta. Am. J. Physiol. 262:C828-C833, 1992.











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